Publications

AUTOMATED INSULIN DELIVERY AT DIABETER

Pim Dekker, Tim van den Heuvel, Arcelia Arrieta, Javier Castañeda, Dick Mul, Henk Veeze, Ohad Cohen, Henk-Jan Aanstoot

Twelve-Month Real-World Use of an Advanced Hybrid Closed-Loop System Versus Previous Therapy in a Dutch Center For Specialized Type 1 Diabetes Care. Journal of Diabetes Science and Technology. 2024;0(0).

MORTALITY AND DIABETES IN THE NETHERLANDS

Jessica Bak, Silvia de Vries, Erik H. Serné, Rolf Groenwold, Harold de Valk, Dick Mul, Theo Sas, Maurice Bizino, Max Nieuwdorp, Mark Kramer, Carianne Verheugt

Mortality patterns in Dutch diabetes outpatients. Diabetes Obes Metab. 2024 Jul 29

‘BIOMARKERS OF HETEROGENEITY IN TYPE 1 DIABETES’ STUDY

HJ Aanstoot, R Varkevisser, D Mul, P Dekker, E Birnie, L Boesten, M Brugts, P van Dijk, N Duijvestijn, S Dutta, C Fransman, R Gonera, K Hoogenberg, A Kooy, E Latres, S Loves, G Nefs, T Sas, C Vollenbrock, M Vosjan-Noeverman, M de Vries-Velraeds, H Veeze, B Wolffenbuttel, M van der Klauw

Cohort profile: The ‘Biomarkers of heterogeneity in type 1 diabetes’ study – a national prospective cohort study of clinical and metabolic phenotyping of individuals with long-standing type 1 diabetes in the Netherlands. BMJ Open 2024 Jun 19;14(6):e082453.

METABOLOMICS AND HYPOGLYCEMIA AWARENESS

Rita Varkevisser, Alexander Cecil, Cornelia Prehn, Dick Mul, Henk-Jan Aanstoot, Andrew Paterson, Bruce Wolffenbuttel, Melanie van der Klauw

Metabolomic associations of impaired awareness of hypoglycaemia in type 1 diabetes. Sci Rep. 2024 Feb 23;14(1):4485.

DIABETES REGISTRY IN THE NETHERLANDS

Jessica Bak, Erik Serné, M Wouters, Harold de Valk, Dick Mul, Theo Sas, Mark Kramer, Max Nieuwdorp, Carianne Verheugt

Potency of quality indicators in Dutch and international diabetes registries. Diabetes Metab Syndr . 2024 Jan;18(1):102920.

SOCIOECONOMIC DIFFERENCES IN DIABETES CARE

Silvia de Vries, Theo Sas, Jessica Bak, Dick Mul, Max Nieuwdorp, Michel Wouters, Carianne Verheugt

Socio-economic disparities in hospital care among Dutch patients with diabetes mellitus. Diabetes Obes Metab. 2024 Jan 16. Online ahead of print.

HOSPITAL SIZE AND T1D CARE

Silvia de Vries, Jessica Bak, Dick Mul, Michel Wouters, Max Nieuwdorp, Carianne Verheugt, Theo Sas.

Does size matter? Hospital volume and resource use in paediatric diabetes care. Diabet Med . 2023 Nov 28:e15260.

DIET AND CLOSED-LOOP SYSTEMS IN T1D

Sarah Koning

Dietary interventions in closed loop systems - Changing clinical nutrition approaches. Oral presentation at ISPAD 2023

LIPIDS & BLOOD PRESSURE IN T1D

Rita Varkevisser, Dick Mul, Henk-Jan Aanstoot, Bruce Wolffenbuttel, Melanie van der Klauw

Differences in lipid and blood pressure measurements between individuals with type 1 diabetes and the general population: a cross-sectional study. BMJ Open 2023;13:e073690

SENSORS & QUALITY OF LIFE IN T1D

Per Winterdijk, Henk-Jan Aanstoot, Giesje Nefs

The impact of real-time sensor technology on quality of life for adults with type 1 diabetes: A Dutch national survey. Diab Res Clin Pract. 203;September 2023;110886

DIABETES AND USE OF HOSPITAL CARE IN THE NETHERLANDS

Silvia de Vries, Jessica Bak, Vincent Stangenberger, Michel Wouters, Max Nieuwdorp, Theo Sas, Carianne Verheugt

Use of hospital care among Dutch diabetes patients. Diabetes Obes Metab . 2023 Aug;25(8):2268-2278.

SLEEP & T1D IN YOUTHS

Giesje Nefs, Richard Feinn, Anne-Marie Chang, Julie Wagner

Longitudinal relations of sleep quality with depressive symptoms, diabetes distress and self-efficacy in young people with type 1 diabetes. J. Psychosom. Res. 2023. 10 August 2023, 111457

BASAL BOLUS RATIO & TREATMENT MODALITY

Ferda Evin, Sascha R. Tittel, Barbara Piccini, Roque Cardona-Hernandez, Dick Mul, Nicole Sheanon, Thekla von dem Berge, Vit Neuman, Martin Tauschmann, Damla Gökşen

Basal and Bolus Insulin Distribution According to Treatment Modality: Data from SWEET Diabetes Registry. Pediatric Diabetes. 2023 Aug 9; 8837506.

PEDIATRIC T1D CARE DURING COVID-19

Agata Chobot, Stefanie Lanzinger, Hessa Alkandari, Todd Alonso, Nicole Blauensteiner, Nicole Coles, Luisa De Sanctis, Dick Mul, Banshi Saboo, Carmel Smart, Meng-Che Tsai, Bedowra Zabeen, Klemen Dovc for the SWEET Study Group

Diabetes care practices and outcomes in 40.000 children and adolescents with type 1 diabetes from the SWEET registry during the COVID-19 pandemic. Diabetes Res Clin Pract. 2023 Jun 27;110809.

INSULIN PUMP DISCONTINUATION

Pim Dekker, Henk-Jan Aanstoot, Theo Sas, Martine de Vries, Erwin Birnie, Dick Mul, Giesje Nefs

Prevalence of and reasons for discontinuation of continuous subcutaneous insulin infusion in people with type 1 diabetes: a systematic review. Diabetes Technol Ther. 2023 Apr 13. Online ahead of print.

COST AND TECHNOLOGY IN PEDIACTRIC DIABETES

Silvia de Vries, Jessica Bak, Carianne Verheugt, Vincent Stangenberger, Dick Mul, Michel Wouters, Max Nieuwdorp, Theo Sas

Healthcare expenditure and technology use in pediatric diabetes care. BMC Endocr Disord. 2023 Apr 7;23(1):72.

NEED FOR IMPROVEMENT IN T1D MANAGEMENT

Rita Varkevisser, Erwin Birnie, Dick Mul, Peter van Dijk, Henk-Jan Aanstoot, Bruce Wolffenbuttel, Melanie van der Klauw

Type 1 diabetes management: Room for improvement. J Diabetes. 2023 Mar;15(3):255-263.

REDUCING FEAR OF HYPOGLYCAEMIA

Hannah Chatwin, Melanie Broadley, Bastiaan de Galan, Ellen Bazelmans, Jane Speight, Frans Pouwer, Giesje Nefs

Effectiveness of educational and behavioural interventions for reducing fear of hypoglycaemia among adults with type 1 diabetes: Systematic review and meta- analyses. Diabet Med. 2023 Feb 17;e15071.

C-PEPTIDE IN LONG-STANDING T1D

Charlotte Vollenbrock, Dick Mul, Pim Dekker, Erwin Birnie, Martine de Vries, Lianne Boesten, Joost Groen, Nel Geelhoed-Duijvestijn, Henk-Jan Aanstoot, Bruce Wolffenbuttel

Fasting and meal-stimulated serum C-peptide in long-standing type 1 diabetes mellitus. Diabet Med . 2023 Feb;40(2):e15012.

SEX DIFFERENCES IN PAEDIATRIC T1D

Silvia de Vries, Carianne Verheugt, Dick Mul, Max Nieuwdorp, Theo Sas

Do sex differences in paediatric type 1 diabetes care exist? A systematic review. Diabetologia. 2023 Apr;66(4):618-630. Epub 2023 Jan 26.

BINGE EATING IN DIABETES

Sasja Huisman, Christel Hendrieckx, Mariska Bot, François Pouwer, Giesje Nefs

Prevalence, associations and health outcomes of binge eating in adults with type 1 or type 2 diabetes: Results from Diabetes MILES –The Netherlands. Diabet Med. 2023 Jan;40(1):e14953.

SLEEP DISTURBANCES IN DIABETES

Femke Rutters, Giesje Nefs

Sleep and Circadian Rhythm Disturbances in Diabetes: A Narrative Review. Diabetes Metab Syndr Obes. 2022 Nov 21;15:3627-3637.

HYPOGLYCEMIA AND COGNITIVE FUNCTION

Clementine Verhulst, Therese Fabricius, Giesje Nefs, Roy Kessels, Frans Pouwer, Steven Teerenstra, Cees Tack, Melanie Broadley, Peter Kristensen, Rory McCrimmon, Simon Heller, Mark Evans, Ulrik Pedersen-Bjergaard, Bastiaan de Galan

Consistent Effects of Hypoglycemia on Cognitive Function in People With or Without Diabetes. Diabetes Care. 2022 Sep 1;45(9):2103-2110.

MENTAL HEALTH AND LIFESTYLE BEHAVIOURS IN DIABETES

Kristel Polhuis, Eline van Bennekom, Mariska Bot, Giesje Nefs, Lenneke Vaandrager, Mirela Habibovic, Johanna Geleijnse, Frans Pouwer, Sabita Soedamah-Muthu

Flourishing mental health and lifestyle behaviours in adults with Type 1 and Type 2 Diabetes Mellitus: results from the Diabetes MILES – The Netherlands Study. Diabetes Care. J Psychosom Res. 2022 Sep;160:110950.

DIABETES VACCINE DIAMYD® (GAD65-ALUM) IMPROVES GLYCEMIC CONTROL IN RECENTLY DIAGNOSED T1D

Christoph Nowak, Marcus Lind, Zdenek Sumnik, et al. (including Theo Sas of Diabeter)

Intralymphatic GAD-Alum (Diamyd®) Improves Glycemic Control in Type 1 Diabetes With HLA DR3-DQ2. J Clin Endocrinol Metab . 2022 Aug 18;107(9):2644-2651.

CARDIOVASCULAR RISK MANAGEMENT IN T1D

Rita Varkevisser, Erwin Birnie, Charlotte Vollenbrock, Dick Mul, Peter van Dijk, Melanie van der Klauw, Henk Veeze, Bruce Wolffenbuttel, Henk-Jan Aanstoot.

Cardiovascular risk management in people with type 1 diabetes: performance using three guidelines. BMJ Open Diabetes Res Care. 2022 Jul;10(4):e002765

CLOSING THE LOOP PART II: 780G SYSTEM RESULTS AFTER 6 MONTHS

D Mul, A. Arrieta, HJ Aanstoot, J Castañeda, J Da Silva

Durable high glucometric performance of the Minimed 780G advanced hybrid closed loop system in real-world evaluation in a value based diabetes center (Diabeter Netherlands). Diabetes Technology & Therapeutics.Apr 2022.A-1-A-237. Poster EP035

GLYCEMIC CONTROL IN T1D: INTERNATIONAL COMPARISON

Regina Prigge, John A McKnight, Sarah H Wild et al. (including Henk Veeze, Henk-Jan Aanstoot and Dick Mul of Diabeter)

International comparison of glycaemic control in people with type 1 diabetes: an update and extension. Diabet Med. 2022 May;39(5):e14766.

COVID-19 AND IMPROVED GLUCOMETRICS IN T1D

Namam Ali, Soumia El Hamdaoui, Giesje Nefs, Cornelis J Tack, Bastiaan E De Galan

Improved glucometrics in people with type 1 diabetes 1 year into the COVID-19 pandemic. BMJ Open Diabetes Res Care . 2022 May;10(3):e002789.

MEASURING DIVISION OF CARE IN T1D

Jori Aalders, Giesje Nefs, Esther Hartman, Linh A. Nguyen, Per Winterdijk, Edgar van Mil, Henk-Jan Aanstoot, Frans Pouwer

A Systematic Review of Instruments Measuring the Division of Care Responsibilities between Children with Type 1 Diabetes and their Parents. Curr Diabetes Rev . 2023;19(5):59-93.

PSYCHOLOGY OF AUTOMATED INSULIN DELIVERY SYSTEMS IN T1D

Giesje Nefs

The Psychological Implications of Automated Insulin Delivery Systems in Type 1 Diabetes Care. Front. Clin. Diabetes Healthc., 2022 May 3;3:846162.

GLYCEMIC VARIABILITY AND PREGNANCY

Riëlle Hoek-Hogchem, Sarah Bovenberg, Pim Dekker, Erwin Birnie, Henk Veeze, Hans J. Duvekot, Sander Galjaard, Henk-Jan Aanstoot

Effects of peri-conception and pregnancy glycemic variability on pregnancy and perinatal complications in type 1 diabetes: a pilot study. Exp Clin Endocrinol Diabetes. 2022 Nov;130(11):740-750.

AVAILABILITY & REPORTING OF TECHNICAL SPECIFICATIONS OF C-PEPTIDE ASSAYS

Pim Dekker, Martine de Vries, Henk-Jan Aanstoot, Joost Groen

Which C-peptide assay do you use? Increasing need for describing C-peptide assay performance. Pediatr Endocrinol Diabetes Metab 2022; 28 (1): 101–103

DEVELOPMENT OF APP FOR REAL-TIME INVESTIGATION OF HYPOGLYCEMIA

Uffe Søholm, Melanie Broadley, Natalie Zaremba, Patrick Divilly, Giesje Nefs, Zeinab Mahmoudi, Bastiaan de Galan, Pedersen-Bjergaard, Alan Brennan, Daniel John Pollard, Rory J McCrimmon, Stephanie A. Amiel, Christel Hendrieckx, Jane Speight, Pratik Choudhary, Frans Pouwer, for the HypoRESOLVE Consortium

Investigating the day-to-day impact of hypoglycaemia in adults with type 1 or type 2 diabetes: design and validation protocol of the HypoMETRICS application. BMJ Open. 2022 Feb 1;12(2):e051651

DEPRESSION & HBA1C IN DIABETES

Magdalena Beran, Rutendo Muzambi, Anouk Geraets, Juan Rafael Albertorio-Diaz, Marcel C. Adriaanse, Marjolein M. Iversen, Andrzej Kokoszka, Giesje Nefs, Arie Nouwen, Frans Pouwer, Jörg W. Huber, Andreas Schmitt, Miranda T. Schram, for the European Depression in Diabetes (EDID) Research Consortium

The bidirectional longitudinal association between depressive symptoms and HbA1c: A systematic review and meta-analysis. Diabet Med . 2022 Feb;39(2):e14671.

DETECTION LIMITS OF C-PEPTIDE ASSAYS IN DIABETES RESEARCH

Kitty de Leur, Charlotte Vollenbrock, Pim Dekker, Martine de Vries, Erwin Birnie, Dick Mul, Bruce H. R. Wolffenbuttel, Joost Groen, Henk-Jan Aanstoot, Lianne Boesten

How low is really low? Comparison of two C-peptide assays to establish residual C-peptide production in type 1 diabetes. Diabet Med. 2022 May;39(5):e14785.

DEPRESSION & ANXIETY IN ADOLESCENTS WITH TYPE 1 DIABETES

Linh A. Nguyen, Frans Pouwer, Paul Lodder, Esther Hartman, Per Winterdijk, Henk-Jan Aanstoot, Giesje Nefs

Depression and anxiety in adolescents with type 1 diabetes and their parents. Pediatr Res . 2022 Jan;91(1):188-196.

CONSENSUS STATEMENT DO-IT-YOURSELF AUTOMATED INSULIN DELIVERY SYSTEMS

Katarina Braune, Rayhan A. Lal, Lenka Petruželková, Gary Scheiner, Per Winterdijk, Signe Schmidt, Linda Raimond, Korey K Hood, Michael C Riddell, Timothy Skinner, Klemens Raile, Sufyan Hussain on behalf of the OPEN International Healthcare Professional Network and OPEN Legal Advisory Group.

Open-source automated insulin delivery: international consensus statement and practical guidance for health-care professionals. Lancet Diabetes Endocrinol . 2022 Jan;10(1):58-74.

C-PEPTIDE AND IMPAIRED AWARENESS OF HYPOGLYCEMIA

Martine J Wellens, Charlotte E Vollenbrock, Pim Dekker, Lianne S M Boesten, Petronella H Geelhoed-Duijvestijn, Martine M C de Vries-Velraeds, Giesje Nefs, Bruce H R Wolffenbuttel , Henk-Jan Aanstoot, Peter R van Dijk

Residual C-peptide secretion and hypoglycemia awareness in people with type 1 diabetes. BMJ Open Diabetes Res Care . 2021 Sep;9(1):e002288.

MINDFULNESS & DIET QUALITY IN DIABETES

Shengxin Liu, Ivan Nyklíček, Frans Pouwer, Jane Speight, Mariska Bot, Giesje Nefs, Sabita S. Soedamah‑Muthu

Mindfulness in Relation to Diet Quality in Adults with Type 1 and Type 2 Diabetes: Results from Diabetes MILES‑The Netherlands. Mindfulness. 2021 Sep;12:2943–2954.

SEXUAL DYSFUNCTIONS IN DIABETES

Jolijn Van Cauwenberghe, Paul Enzlin, Giesje Nefs, Johannes Ruige, Christel Hendrieckx, Christophe De Block, Frans Pouwer

Prevalence of and risk factors for sexual dysfunctions in adults with type 1 or type 2 diabetes: Results from Diabetes MILES -Flanders. Diabet Med . 2022 Jan;39(1):e14676. Epub 2021 Sep 1.

HYPOGLYCEMIA & QUALITY OF LIFE IN ADOLESCENTS WITH TYPE 1 DIABETES

Manon Coolen, Jori Aalders, Melanie Broadley, Henk-Jan Aanstoot, Esther Hartman, Christel Hendrieckx, Giesje Nefs, Frans Pouwer

Hypoglycaemia and diabetes-specific quality of life in adolescents with type 1 diabetes. Diabet Med . 2021 Aug;38(8):e14565.

SWEET: BENCHMARKING TYPE 1 DIABETES CARE IN 19 COUNTRIES

Peter Gerhardsson, Anke Schwandt, Michael Witsch, Olga Kordonouri, Jannet Svensson, Gun Forsander, Tadej Battelino, Henk Veeze, Thomas Danne, on Behalf of the SWEET Study Group

The SWEET Project 10-Year Benchmarking in 19 Countries Worldwide Is Associated with Improved HbA1c and Increased Use of Diabetes Technology in Youth with Type 1 Diabetes. 2021 Jul;23(7):491-499.

DIAGNODE-2: RESULTS FROM TRIAL WITH DIABETES VACCINE DIAMYD® (GAD65-ALUM) PUBLISHED

Johnny Ludvigsson, Zdenek Sumnik, Terezie Pelikanova, et al. (including Theo Sas of Diabeter)

Intralymphatic Glutamic Acid Decarboxylase With Vitamin D Supplementation in Recent-Onset Type 1 Diabetes: A Double-Blind, Randomized, Placebo-Controlled Phase IIb Trial. Diabetes Care . 2021 Jul;44(7):1604-1612.

REMOTE CARE IN COVID-19 TIMES

G Nefs, P Winterdijk, P Dekker, M De Vries, T Sas, D Mul, H Veeze, HJ Aanstoot

Transition to remote diabetes care in COVID-19 times: experiences from a specialized type 1 diabetes clinic. 14th International Conference on Advanced Technologies and Treatments for Diabetes, 2-5 June 202, online. Abstract: #359.

CLOSING THE LOOP: 780G SYSTEM

HJ Aanstoot, P Winterdijk, S Bovenberg, P Dekker, M De Vries, T Sas, D Mul, I Bliek, S Huijbers, M Alkemade, L Olierook, H Veeze

Effect of remote education in switching to a new advanced hybrid closed-loop system: improved time in range, sustained auto mode and better average glucose levels. 14th International Conference on Advanced Technologies and Treatments for Diabetes, 2-5 June 2021, online. Abstract: #319.

DUTCH NATIONAL DIABETES REGISTRY: DPARD

Jessica C. G. Bak, Dick Mul, Erik H. Serné, Harold W. de Valk, Theo C. J. Sas, Petronella H. Geelhoed-Duijvestijn, Mark H. H. Kramer, Max Nieuwdorp, Carianne L. Verheugt

DPARD: rationale, design and initial results from the Dutch national diabetes registry. BMC Endocr Disord. 2021 Jun 16;21(1):122.

MOOD/ANXIETY DISORDERS IN ADOLESCENTS WITH TYPE 1 DIABETES

Linh Anh Nguyen, Frans Pouwer, Per Winterdijk, Esther Hartman, Roos Nuboer, Theo Sas, Ineke de Kruijff, Willie Bakker-Van Waarde, Henk-Jan Aanstoot, Giesje Nefs

Prevalence and course of mood and anxiety disorders, and correlates of symptom severity in adolescents with type 1 diabetes: Results from diabetes LEAP. Pediatr Diabetes. 2021 Jun; 22(4):638-648.

TRANSFERRING RESPONSIBILITY FROM PARENTS TO CHILDREN IN TYPE 1 DIABETES

Jori Aalders , Esther Hartman, Frans Pouwer, Per Winterdijk, Edgar van Mil, Angelique Roeleveld-Versteegh, Elke Mommertz-Mestrum Henk-Jan Aanstoot, Giesje Nefs

The division and transfer of care responsibilities in paediatric type 1 diabetes: A qualitative study on parental perspectives. J Adv Nurs . 2021 Apr;77(4):1968-1979.

PRIMARY VS SECONDARY PATIENTS: THE DIABETER EXPERIENCE

P Dekker,D Mul, M De Vries, T Sas, HJ Aanstoot, H Veeze.

Glycaemic control in type 1 diabetes patients treated from clinical onset in a value-based care center vs. patients transferred from other centers: the DIABETER experience. 13th International Conference on Advanced Technologies and Treatments for Diabetes, 19-22 February 2020, Madrid. Abstract: #628.

REAL-WORLD DATA 670G HYBRID CLOSED-LOOP SYSTEM

Dick Mul, Arcelia Arrieta, Pim Dekker, Henk-Jan Aanstoot, Martine de Vries, Theo Sas, Henk Veeze

Increased time in range and sustained Auto Mode use in 670G hybrid closed-loop system users: real world experience in DIABETER. 13th International Conference on Advanced Technologies and Treatments for Diabetes, 19-22 February 2020, Madrid, Spain. Abstract: #170.

OPTIMIZING SCREENING OF LIPIDS IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES

Heyden JCV, Birnie E, Bovenberg SA, Dekker P, Veeze HJ, Mul D, Aanstoot HJ.

Losing Track of Lipids in Children and Adolescents with Type 1 Diabetes: Towards Individualized Patient Care. Exp Clin Endocrinol Diabetes. 2021 Jul;129(7):510-518.

THE QUALIMETER: IMPROVING DISCUSSIONS ON QUALITY OF LIFE

Donkers E, Dekker P, Winterdijk P, Mul D, Sas T, de Vries M, Veeze HJ, Aanstoot HJ, Nefs G, Eilander M.

The Qualimeter: Improving care for children and adults with type 1 diabetes by measuring and discussing Quality of Life. ICHOM 2019 conference.

EMOTIONAL PROBLEMS IN ADOLESCENTS WITH TYPE 1 DIABETES AND THEIR PARENTS/CAREGIVERS

Nefs G, Nguyen L, Winterdijk P, Hartman E, Sas T, Nuboer R, De Kruijff I, Bakker-van Waarde W, Aanstoot HJ, Pouwer F.

Study protocol of Diabetes LEAP: a Longitudinal study Examining emotional problems in Adolescents with type 1 diabetes and their Parents/caregivers. BMC Pediatr. 2019; 19: 377.

FRAMEWORK CONDITIONS FOR SUCCESFUL USE OF TECHNOLOGY IN TYPE 1 DIABETES

Mul D, Aanstoot HJ, Dekker P, de Vries M, Sas T, Veeze HJ.

Improvement of A1C can be obtained in an optimal and enabling setting that combines technology and patient-HCP contacts through data-upload and eHealth. 45th Annual of the International Society for Pediatric and Adolescent Diabetes (ISPAD), Oct 30-Nov 2 2019, Abstract: #O23

TO PUMP OR NOT TO PUMP: CSII DISCONTINUATION AMONG CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES

T Sas, C De Jong, M De Vries, P Dekker, HJ Aanstoot, H Veeze, D Mul.

Discontinuation of pump use in children and adolescents with type 1 diabetes. 12th International Conference on Advanced Technologies and Treatments for Diabetes, 20-23 February 2019, Berlin. Abstract: #279.

PEDIATRIC TYPE 1 DIABETES: A FAMILY DISEASE

Nieuwesteeg AM, Hartman EE, Aanstoot HJ, van Bakel HJ, Emons WH, van Mil E, Pouwer F.

The relationship between parenting stress and parent-child interaction with health outcomes in the youngest patients with type 1 diabetes (0-7 years). Eur J Pediatr. 2016;175:329-38.

CAROTID INTIMA MEDIA THICKNESS (CIMT) INCREASED IN PEOPLE WITH TYPE 1 DIABETES

Van der Heyden JC, Birnie E, Bovenberg SA, Cabezas MC, van der Meulen N, Mul D, Veeze HJ, Aanstoot HJ.

Do traditional cardiovascular risk factors solely explain intima-media thickening in youth with type 1 diabetes? J Diabetes Complications. 2016 Aug;30(6):1137-43.

SKIN AUTOFLUORESCENCE COULD BE EARLY SURROGATE MARKER FOR DIABETIC COMPLICATIONS

van der Heyden JC, Birnie E, Mul D, Bovenberg S, Veeze HJ, Aanstoot HJ.

Increased skin autofluorescence of children and adolescents with type 1 diabetes despite a well-controlled HbA1c: results from an observational cohort study. BMC Endocr Disord. 2016 Sep 9;16(1):49.

GADA PERSISTENCE AND DIABETES CLASSIFICATION

Ten Kate Q, Aanstoot HJ, Birnie E, Veeze H, Mul D.

GADA persistence and diabetes classification. Lancet Diabetes Endocrinol. 2016;4:563–564.

INCIDENCE OF PEDIATRIC TYPE 1 DIABETES DOUBLES IN 30 YEARS

Spaans EA, Gusdorf LM, Groenier KH, Brand PL, Veeze HJ, Reeser HM, Bilo HJ, Kleefstra N.

The incidence of type 1 diabetes is still increasing in the Netherlands, but has stabilised in children under five (Young DUDEs-1). Acta Pediatr. 2015;104:626-9.

DINO STUDY TO PROVIDE NEW INSIGHTS INTO PEDIATRIC TYPE 1 DIABETES

Eilander MM, de Wit M, Rotteveel J, Aanstoot HJ, Waarde WM, Houdijk EC, Luman M, Nuboer R, Oosterlaan J, Winterdijk P, Snoek FJ.

Diabetes IN development (DINO): the bio-psychosocial, family functioning and parental well-being of youth with type 1 diabetes: a longitudinal cohort study design. BMC Pediatrics. 2015;15:82.

GLOBAL STUDY COMPARES GLYCEMIC CONTROL RATES

McKnight JA, Wild SH, Lamb MJ, Cooper MN, Jones TW, Davis EA, Hofer S et al.

Glycaemic control of type 1 diabetes in clinical practice early in the 21st century: an international comparison. Diabet Med. 2015;32:1036-50.

INSULIN DOSING CALCULATOR FOR PEOPLE WITH NEWLY DEVELOPED TYPE 1 DIABETES EVALUATED

Mul D, Aanstoot HJ, Simm D, Veeze HJ.

Initial insulin dosage in new onset pediatric diabetes: how to start? Presented at: 8th International Conference on Advanced Technologies and Treatments for Diabetes, 18-21 February 2015, Paris. Abstract: #286.

THYROID PEROXIDASE AUTOIMMUNITY IN TYPE 1 DIABETES – HOW PREVALENT IS IT?

D. Simm, E.Birnie, D. Mul, H.J. Veeze, H.J. Aanstoot.

Thyroid peroxidase autoimmunity and the effect on thyroid function in children and adolescents with type 1 diabetes. Presented at: 8th International Conference on Advanced Technologies and Treatments for Diabetes, 18-21 February 2015, Paris. Abstract: #376.

CAN SUBCLINICAL NERVE DYSFUNCTION BE DETECTED EARLY?

Van der Heyden J, van der Meer P, Birnie E, de Coo IF, Castro Cabezas M, Ozcan B, Veeze H, Visser GH, Aanstoot HJ, Blok JH.

Decreased excitability of the distal motor nerve of young patients with type 1 diabetes mellitus. Pediatr Diabetes. 2013;14:519-25.

QUESTIONNAIRE ASSESSES DIABETES-RELATED QOL

De Wit M, Winterdijk P, Aanstoot HJ, Anderson B, Danne T, Deeb L, Lange K, Nielsen AØ, Skovlund S, Peyrot M, Snoek F; DAWN Youth Advisory Board.

Assessing diabetes-related quality of life in youth with type 1 diabetes in routine clinical care: the MIND Youth Questionnaire (MY-Q). Pediatr Diabetes. 2012;13:638-46.

REVIEW ASSESSES IMPACT OF TYPE 1 DIABETES ON QUALITY OF LIFE

Nieuwesteeg A, Pouwer F, van der Kamp R, van Bakel H, Aanstoot HJ, Hartman E.

Quality of life of children with type 1 diabetes: a systematic review. Curr Diabetes Rev. 2012;8:434-43.

FAMILY FACTORS INFLUENCE PATIENT OUTCOMES

Cameron FJ, Skinner TC, de Beaufort CE, Hoey H, Swift PG, Aanstoot H, Aman J, Martul P et al.

Are family factors universally related to metabolic outcomes in adolescents with type 1 diabetes? Diabet Med. 2008;25:463-8.