The formation of advanced glycation end-products (AGEs) is increased by the hyperglycemic and inflammatory conditions of diabetes. While studies have shown the importance and applicability of AGEs in adults, data in children and adolescents are relatively limited.

Our data from using non-invasive skin autofluorescence testing to measure levels of AGEs in our young population of people wth type 1 diabetes showed that AGE levels correlated with levels of diabetes-related damage. Individual variations pointing to the role of genetic and environmental factors are now being studied in the JDRF-funded Biomarker study in collaboration with Prof. Bruce Wolffenbuttel at the UMCG.

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